Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy
TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical Reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-
proteasome system that recruits substrates such as the hypoxia inducible factor for …
proteasome system that recruits substrates such as the hypoxia inducible factor for …
[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
Recent advances in active targeting of nanomaterials for anticancer drug delivery
One of the challenges in cancer chemotherapy is the low target to non-target ratio of
therapeutic agents which incur severe adverse effect on the healthy tissues. In this regard …
therapeutic agents which incur severe adverse effect on the healthy tissues. In this regard …
Deubiquitylating enzymes and drug discovery: emerging opportunities
JA Harrigan, X Jacq, NM Martin… - Nature reviews Drug …, 2018 - nature.com
More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …
E-cadherin in contact inhibition and cancer
AM Mendonsa, TY Na, BM Gumbiner - Oncogene, 2018 - nature.com
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …
[PDF][PDF] The advantages of targeted protein degradation over inhibition: an RTK case study
Proteolysis targeting chimera (PROTAC) technology has emerged over the last two decades
as a powerful tool for targeted degradation of endogenous proteins. Herein we describe the …
as a powerful tool for targeted degradation of endogenous proteins. Herein we describe the …
[HTML][HTML] Immunology and immunotherapy of head and neck cancer
RL Ferris - Journal of clinical oncology, 2015 - ncbi.nlm.nih.gov
The immune system plays a key role in the development, establishment, and progression of
head and neck squamous cell carcinoma (HNSCC). A greater understanding of the …
head and neck squamous cell carcinoma (HNSCC). A greater understanding of the …
Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances
Liver cancer is considered one of the deadliest diseases with one of the highest disease
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …
Chimeric antigen receptor T cells: a novel therapy for solid tumors
The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive
antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor …
antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor …