[HTML][HTML] CRISPR/Cas-based approaches to study schizophrenia and other neurodevelopmental disorders

AO Kurishev, DS Karpov, NI Nadolinskaia… - International Journal of …, 2022 - mdpi.com
The study of diseases of the central nervous system (CNS) at the molecular level is
challenging because of the complexity of neural circuits and the huge number of specialized …

[HTML][HTML] An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders

X Zeng, Y Cai, M Wu, H Chen, M Sun… - Journal of …, 2024 - Springer
The adverse use of alcohol is a serious global public health problem. Maternal alcohol
consumption during pregnancy usually causes prenatal alcohol exposure (PAE) in the …

[HTML][HTML] Blood–Brain Barrier Integrity Is Perturbed in a Mecp2-Null Mouse Model of Rett Syndrome

G Pepe, S Fioriniello, F Marracino, L Capocci… - Biomolecules, 2023 - mdpi.com
Rett syndrome (RTT, online MIM 312750) is a devastating neurodevelopmental disorder
characterized by motor and cognitive disabilities. It is mainly caused by pathogenetic …

[HTML][HTML] Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence

MKY Cealie, JC Douglas, LHD Le… - Frontiers in …, 2023 - frontiersin.org
Introduction Fetal alcohol spectrum disorders (FASD) are the most common cause of non-
heritable, preventable mental disability, occurring in almost 5% of births in the United States …

[HTML][HTML] Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess neuronal epitranscriptome plasticity

O Fanari, S Tavakoli, S Akeson, A Makhamreh, K Nian… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Chemical modifications in mRNAs such as pseudouridine (psi) can regulate gene
expression, although our understanding of the functional impact of individual psi …

Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles

Y Iitani, R Miki, K Imai, K Fuma, T Ushida, S Tano… - Pediatric …, 2024 - nature.com
Background Increased maternal interleukin (IL)-17A and activated microglia are pivotal
factors contributing to the pathological phenotypes of maternal immune activation (MIA) …

Neuroinflammatory syndromes in children

AJ Hauptman, V Ferrafiat - Current opinion in psychiatry, 2023 - journals.lww.com
Neuroimmunological disease data are constantly evolving. New recommendations exist for
multiple common neuroimmunological disorders with behavioural, emotional, cognitive and …

Autism spectrum disorder and a possible role of anti-inflammatory treatments: experience in the pediatric allergy/immunology clinic

H Jyonouchi - Frontiers in Psychiatry, 2024 - frontiersin.org
Autism spectrum disorder (ASD1) is a behaviorally defined syndrome encompassing a
markedly heterogeneous patient population. Many ASD subjects fail to respond to the 1st …

[HTML][HTML] Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment

H Jyonouchi, L Geng, DA Rossignol… - Journal of Personalized …, 2022 - mdpi.com
COVID-19 causes not only severe respiratory symptoms, but also long-term sequelae, even
if the acute-phase symptoms are minor. Neurological and neuropsychiatric symptoms are …

[HTML][HTML] Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders

RM Woods, JM Lorusso, J Fletcher, H ElTaher… - Neuronal …, 2023 - portlandpress.com
Maternal infection during pregnancy, leading to maternal immune activation (mIA) and
cytokine release, increases the offspring risk of developing a variety of neurodevelopmental …