The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …

Congenital heart disease is a major cause of morbidity and mortality throughout life.
Mutations in numerous transcription factors have been identified in patients and families with …

Mutation of highly conserved residues in transcription factors may affect protein-protein or
protein-DNA interactions, leading to gene network dysregulation and human disease …

Ventricular septal defects account for up to 40% of all congenital cardiac malformations. The
diagnosis encompasses a broad range of anomalies, including isolated defects and those …

During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …

Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Cardiogenesis in mammals requires exquisite control of gene expression and faulty
regulation of transcriptional programs underpins congenital heart disease (CHD), the most …

Congenital heart disease (CHD) is the most common birth defect worldwide and the number
one killer of live-born infants in the United States. Heart development occurs early in …

TBX1, encoding a T-box containing transcription factor, is the major candidate gene for
del22q11. 2 or DiGeorge syndrome, characterized by craniofacial and cardiovascular …

In this review, we discuss current evidence linking environmental pollutants to
cardiovascular disease (CVD). Extensive evidence indicates that environmental factors …