Sparsentan: the first and only non-immunosuppressive therapy for the reduction of proteinuria in IgA nephropathy

H Trachtman, R Komers, J Inrig - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction IgA nephropathy is one of the most common forms of glomerular disease.
Patients with persistent proteinuria are at increased risk of progression to kidney failure …

Contemporary review of IgA nephropathy

EJ Filippone, R Gulati, JL Farber - Frontiers in Immunology, 2024 - frontiersin.org
IgA nephropathy (IgAN) is considered the most common primary glomerulonephritis
worldwide with a predilection for Asian-Pacific populations and relative rarity in those of …

An open-label study evaluating the safety and efficacy of budesonide in patients with IgA nephropathy at high risk of progression

B Obrișcă, A Vornicu, V Mocanu, G Dimofte… - Scientific Reports, 2023 - nature.com
We sought to evaluate the efficacy and safety of budesonide (Budenofalk) in the treatment of
patients with IgA Nephropathy. We conducted a prospective, interventional, open-label …

Efficacy of traditional Chinese medicine versus angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and their combinations in the treatment of …

S Ma, Y Jiang, L Qian, M Wang, S Xu… - Frontiers in …, 2024 - frontiersin.org
Background: IgA nephropathy (IgAN), a condition posing a significant threat to public health,
currently lacks a specific treatment protocol. Research has underscored the potential …

Drugs in Development to Treat IgA Nephropathy

L Del Vecchio, M Allinovi, S Comolli, S Peiti, C Rimoldi… - Drugs, 2024 - Springer
IgA nephropathy is a common glomerulonephritis consequent to the autoimmune response
to aberrant glycosylated immunoglobulin (Ig) A antibodies. Although it has historically been …

Immune checkpoint inhibitor therapy associated with IgA nephropathy: a case report and literature review

M Chabannes, Z Lisri, S Lang, J Seibel… - Frontiers in …, 2024 - frontiersin.org
Immune checkpoint inhibitors (ICIs) dramatically improve the prognosis of many
malignancies but at the cost of numerous side effects, which may limit their benefits. Acute …

Preclinical characterization of a novel investigational monoclonal antibody CM313 with potent CD38-positive cell killing activity

W Liu, J Yu, K Sun, Q Song, Y Li, Y He… - Frontiers in …, 2024 - frontiersin.org
Introduction CM313 is currently under clinical investigation for treatments of multiple
myeloma, systemic lupus erythematosus, and immune thrombocytopenia. We aimed to …

Podocyte injury as a potential therapeutic target in IgA nephropathy: should pathology guide us?

M Haas - Kidney International, 2024 - Elsevier
The Oxford histopathologic classification (MEST-C: scores for lesions indicating active
glomerular inflammation, mesangial [M] and endocapillary [E] hypercellularity as well as …

Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study …

H Komatsu, S Fujimoto, Y Sato, T Yasuda… - Clinical and …, 2024 - Springer
Background The effects of tonsillectomy combined with steroid pulse (TSP) therapy for IgA
nephropathy (IgAN) are little known. Therefore, we examined the effects of TSP therapy on …

[HTML][HTML] Exploring Novel Adverse Events of Nefecon

J Wang, Z Zhang, X Liu, S Shi, J Lv, Y Zhang… - Kidney International …, 2024 - Elsevier
Introduction Nefecon, the first innovative drug approved by both the US Food and Drug
Administration (FDA) and European Medicines Agency for IgA nephropathy (IgAN), lacked …