Sparsentan: the first and only non-immunosuppressive therapy for the reduction of proteinuria in IgA nephropathy
H Trachtman, R Komers, J Inrig - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction IgA nephropathy is one of the most common forms of glomerular disease.
Patients with persistent proteinuria are at increased risk of progression to kidney failure …
Patients with persistent proteinuria are at increased risk of progression to kidney failure …
Contemporary review of IgA nephropathy
EJ Filippone, R Gulati, JL Farber - Frontiers in Immunology, 2024 - frontiersin.org
IgA nephropathy (IgAN) is considered the most common primary glomerulonephritis
worldwide with a predilection for Asian-Pacific populations and relative rarity in those of …
worldwide with a predilection for Asian-Pacific populations and relative rarity in those of …
An open-label study evaluating the safety and efficacy of budesonide in patients with IgA nephropathy at high risk of progression
We sought to evaluate the efficacy and safety of budesonide (Budenofalk) in the treatment of
patients with IgA Nephropathy. We conducted a prospective, interventional, open-label …
patients with IgA Nephropathy. We conducted a prospective, interventional, open-label …
Efficacy of traditional Chinese medicine versus angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and their combinations in the treatment of …
S Ma, Y Jiang, L Qian, M Wang, S Xu… - Frontiers in …, 2024 - frontiersin.org
Background: IgA nephropathy (IgAN), a condition posing a significant threat to public health,
currently lacks a specific treatment protocol. Research has underscored the potential …
currently lacks a specific treatment protocol. Research has underscored the potential …
Drugs in Development to Treat IgA Nephropathy
L Del Vecchio, M Allinovi, S Comolli, S Peiti, C Rimoldi… - Drugs, 2024 - Springer
IgA nephropathy is a common glomerulonephritis consequent to the autoimmune response
to aberrant glycosylated immunoglobulin (Ig) A antibodies. Although it has historically been …
to aberrant glycosylated immunoglobulin (Ig) A antibodies. Although it has historically been …
Immune checkpoint inhibitor therapy associated with IgA nephropathy: a case report and literature review
M Chabannes, Z Lisri, S Lang, J Seibel… - Frontiers in …, 2024 - frontiersin.org
Immune checkpoint inhibitors (ICIs) dramatically improve the prognosis of many
malignancies but at the cost of numerous side effects, which may limit their benefits. Acute …
malignancies but at the cost of numerous side effects, which may limit their benefits. Acute …
Preclinical characterization of a novel investigational monoclonal antibody CM313 with potent CD38-positive cell killing activity
W Liu, J Yu, K Sun, Q Song, Y Li, Y He… - Frontiers in …, 2024 - frontiersin.org
Introduction CM313 is currently under clinical investigation for treatments of multiple
myeloma, systemic lupus erythematosus, and immune thrombocytopenia. We aimed to …
myeloma, systemic lupus erythematosus, and immune thrombocytopenia. We aimed to …
Podocyte injury as a potential therapeutic target in IgA nephropathy: should pathology guide us?
M Haas - Kidney International, 2024 - Elsevier
The Oxford histopathologic classification (MEST-C: scores for lesions indicating active
glomerular inflammation, mesangial [M] and endocapillary [E] hypercellularity as well as …
glomerular inflammation, mesangial [M] and endocapillary [E] hypercellularity as well as …
Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study …
H Komatsu, S Fujimoto, Y Sato, T Yasuda… - Clinical and …, 2024 - Springer
Background The effects of tonsillectomy combined with steroid pulse (TSP) therapy for IgA
nephropathy (IgAN) are little known. Therefore, we examined the effects of TSP therapy on …
nephropathy (IgAN) are little known. Therefore, we examined the effects of TSP therapy on …
[HTML][HTML] Exploring Novel Adverse Events of Nefecon
J Wang, Z Zhang, X Liu, S Shi, J Lv, Y Zhang… - Kidney International …, 2024 - Elsevier
Introduction Nefecon, the first innovative drug approved by both the US Food and Drug
Administration (FDA) and European Medicines Agency for IgA nephropathy (IgAN), lacked …
Administration (FDA) and European Medicines Agency for IgA nephropathy (IgAN), lacked …