Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism …

Poor response to cancer therapy due to resistance remains a clinical challenge. The present
study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic …

Research has indicated that hypoxia profoundly contributes to chemoresistance of
pancreatic cancer (PC), while the precise mechanism has not been fully elucidated. In this …

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to
cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor …

The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Multidrug resistance is the most widely exploited phenomenon by which cancer eludes
chemotherapy. Broad variety of factors, ranging from the cellular ones, such as over …

Simple Summary Accumulating evidence indicates that hypoxia-inducible factor-1 (HIF-1)
plays a pivotal role in tumor biology, particularly in hypoxic environments. Over the past few …

Drug resistance contributes to poor therapeutic response in urothelial carcinoma (UC).
Metabolomic analysis suggested metabolic reprogramming in gemcitabine‐resistant …