Structural mechanism of muscle contraction
MA Geeves, KC Holmes - Annual review of biochemistry, 1999 - annualreviews.org
▪ Abstract X-ray crystallography shows the myosin cross-bridge to exist in two conformations,
the beginning and end of the “power stroke.” A long lever-arm undergoes a 60° to 70° …
the beginning and end of the “power stroke.” A long lever-arm undergoes a 60° to 70° …
The structural basis of muscle contraction
KC Holmes, MA Geeves - … of the Royal Society of London …, 2000 - royalsocietypublishing.org
The myosin cross–bridge exists in two conformations, which differ in the orientation of a long
lever arm. Since the lever arm undergoes a 60° rotation between the two conformations …
lever arm. Since the lever arm undergoes a 60° rotation between the two conformations …
Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution
J Ecken, SM Heissler, S Pathan-Chhatbar, DJ Manstein… - Nature, 2016 - nature.com
The interaction of myosin with actin filaments is the central feature of muscle contraction and
cargo movement along actin filaments of the cytoskeleton. The energy for these movements …
cargo movement along actin filaments of the cytoskeleton. The energy for these movements …
Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM
F Merino, S Pospich, J Funk, T Wagner… - Nature structural & …, 2018 - nature.com
The function of actin is coupled to the nucleotide bound to its active site. ATP hydrolysis is
activated during polymerization; a delay between hydrolysis and inorganic phosphate (Pi) …
activated during polymerization; a delay between hydrolysis and inorganic phosphate (Pi) …
[HTML][HTML] Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: Visualization of the pre–power stroke state
R Dominguez, Y Freyzon, KM Trybus, C Cohen - Cell, 1998 - cell.com
The crystal structures of an expressed vertebrate smooth muscle myosin motor domain (MD)
and a motor domain–essential light chain (ELC) complex (MDE), both with a transition state …
and a motor domain–essential light chain (ELC) complex (MDE), both with a transition state …
[图书][B] Handbook on metalloproteins
I Bertini, A Sigel - 2001 - taylorfrancis.com
This Handbook on Metalloproteins focuses on the available structural information of proteins
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …
[HTML][HTML] Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head
A Houdusse, VN Kalabokis, D Himmel… - Cell, 1999 - cell.com
The crystal structure of a proteolytic subfragment from scallop striated muscle myosin,
complexed with MgADP, has been solved at 2.5 Å resolution and reveals an unusual …
complexed with MgADP, has been solved at 2.5 Å resolution and reveals an unusual …
Three conformational states of scallop myosin S1
A Houdusse, AG Szent-Györgyi… - Proceedings of the …, 2000 - National Acad Sciences
We have determined the structure of the intact scallop myosin head, containing both the
motor domain and the lever arm, in the nucleotide-free state and in the presence of …
motor domain and the lever arm, in the nucleotide-free state and in the presence of …
[HTML][HTML] Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity
DA Winkelmann, E Forgacs, MT Miller… - Nature …, 2015 - nature.com
Omecamtiv Mecarbil (OM) is a small molecule allosteric effector of cardiac myosin that is in
clinical trials for treatment of systolic heart failure. A detailed kinetic analysis of cardiac …
clinical trials for treatment of systolic heart failure. A detailed kinetic analysis of cardiac …
Two independent mechanical events in the interaction cycle of skeletal muscle myosin with actin
M Capitanio, M Canepari… - Proceedings of the …, 2006 - National Acad Sciences
During skeletal muscle contraction, regular arrays of actin and myosin filaments slide past
each other driven by the cyclic ATP-dependent interaction of the motor protein myosin II (the …
each other driven by the cyclic ATP-dependent interaction of the motor protein myosin II (the …