The NLRP3 inflammasome: A vital player in inflammation and mediating the anti-inflammatory effect of CBD
F Chu, X Wang, B Li, L Xu, B Di - Inflammation Research, 2024 - Springer
Background The NLRP3 inflammasome is a vital player in the emergence of inflammation.
The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation …
The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation …
[HTML][HTML] The role of epithelial cells in fibrosis: mechanisms and treatment
L Luo, W Zhang, S You, X Cui, H Tu, Q Yi, J Wu… - Pharmacological …, 2024 - Elsevier
Fibrosis is a pathological process that affects multiple organs and is considered one of the
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …
Demethylzeylasteral protects against renal interstitial fibrosis by attenuating mitochondrial complex I-mediated oxidative stress
P Shen, X Deng, T Li, X Chen, X Wu - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Renal interstitial fibrosis (RIF) is a main pathological
process in chronic kidney disease (CKD). Demethylzeylasteral (DML), a major component of …
process in chronic kidney disease (CKD). Demethylzeylasteral (DML), a major component of …
Predicting the potential mechanism of radix chimonanthi pracecocis in treating osteoarthritis by network pharmacology analysis combined with experimental validation
X Zhang, D Wu, L Zhang, H Zhang, L Yang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Radix Chimonanthi Pracecocis (RCP), also
known as Tiekuaizi, widely used by the Miao community in Guizhou, exhibits diverse …
known as Tiekuaizi, widely used by the Miao community in Guizhou, exhibits diverse …
Inhibition of the NF-κB Signaling Pathway Alleviates Pyroptosis in Bladder Epithelial Cells and Neurogenic Bladder Fibrosis
J Chen, Q Li, Y Hong, X Zhou, C Yu, X Tian… - International Journal of …, 2023 - mdpi.com
Most children with a neurogenic bladder (NB) have bladder fibrosis, which causes
irreversible bladder dysfunction and damage to the upper urinary tract. However, the …
irreversible bladder dysfunction and damage to the upper urinary tract. However, the …
Endogenous stimuli-responsive drug delivery nanoplatforms for kidney disease therapy
H Fang, S Xu, Y Wang, H Yang, D Su - Colloids and Surfaces B …, 2023 - Elsevier
Kidney disease is one of the most life-threatening health problems, affecting millions of
people in the world. Commonly used steroids and immunosuppressants often fall …
people in the world. Commonly used steroids and immunosuppressants often fall …
REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma
The RE1 silencing transcription factor (REST) is a driver of sonic hedgehog (SHH)
medulloblastoma genesis. Our previous studies showed that REST enhances cell …
medulloblastoma genesis. Our previous studies showed that REST enhances cell …
Fangji Huangqi decoction ameliorates membranous nephropathy through the upregulation of BNIP3-mediated mitophagy
Y Wang, Y Ma, Y Ke, X Jiang, J Liu, Y Xiao… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Fangji Huangqi Decoction (FJHQ), a traditional
Chinese medicinal formula outlined in Zhang Zhongjing's “Jin Gui Yao Lue” during the Han …
Chinese medicinal formula outlined in Zhang Zhongjing's “Jin Gui Yao Lue” during the Han …
C/EBPβ–TFAM-Mediated NLRP3 Inflammasome Activation Contributes to Arsenic-Induced Rat Kidney Injury
Z Wu, W Wang, K Zhu, D Luo, A Zhang - Toxics, 2023 - mdpi.com
Compelling evidence has demonstrated that arsenic (As) exposure is associated with kidney
injuries. Given that inflammatory responses and immune imbalances are the root causes of …
injuries. Given that inflammatory responses and immune imbalances are the root causes of …
Role of mitochondria in pathogenesis and therapy of renal fibrosis
X Zhao, Y Li, J Yu, H Teng, S Wu, Y Wang, H Zhou, F Li - Metabolism, 2024 - Elsevier
Renal fibrosis, specifically tubulointerstitial fibrosis, represents the predominant pathological
consequence observed in the context of progressive chronic kidney conditions. The …
consequence observed in the context of progressive chronic kidney conditions. The …