Why do we get cancer mostly when we are old? According to current paradigms, the answer
is simple: mutations accumulate in our tissues throughout life, and some of these mutations …

In response to a variety of stresses, mammalian cells undergo a persistent proliferative
arrest known as cellular senescence. Many senescence‐inducing stressors are potentially …

One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

The skin harbors a variety of resident leukocyte subsets that must be tightly regulated to
maintain immune homeostasis. Hair follicles are unique structures in the skin that contribute …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …

Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …