Ovarian cancer is not a single disease and can be subdivided into at least five different
histological subtypes that have different identifiable risk factors, cells of origin, molecular …

Women in the UK have a 15% lifetime risk of developing breast cancer. Like other high‐
income countries, women in the UK are having children later in life which increases their …

In 2018, there will be approximately 22,240 new cases of ovarian cancer diagnosed and
14,070 ovarian cancer deaths in the United States. Herein, the American Cancer Society …

Purpose Breast cancer (BC) risk prediction allows systematic identification of individuals at
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …

Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

PTEN, CDH1, STK11, MLH1, MSH2, MSH6 and PMS2. The cancer risk association with
other genes, such as PALB2, CHEK2, ATM, RAD51C, RAD51D and BRIP1, is still under …

Ovarian cancer is the fifth-leading cause of cancer-related death in women. The strongest
known risk factors are familial genetic syndromes, such as BRCA gene mutations and …

Importance Young women with breast cancer who have germline pathogenic variants
inBRCA1orBRCA2face unique challenges regarding fertility. Previous studies …

BRCA1-and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is
characterized by an increased risk for female and male breast cancer, ovarian cancer …