Rabbits are one of the most used experimental animals for investigating the mechanisms of
human cardiovascular disease and lipid metabolism because they are phylogenetically …

Cardiovascular disease is the largest single cause of disease-related mortality worldwide
and the major underlying pathology is atherosclerosis. Atherosclerosis develops as a …

Existing animal models of cystic fibrosis (CF) have provided key insights into CF
pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or …

Recombinant proteins are essential for the treatment and diagnosis of clinical human
ailments. The availability and biological activity of recombinant proteins is heavily influenced …

The rabbit is a classic animal model for biomedical research, but the production of gene
targeted transgenic rabbits had been extremely challenging until the recent advent of gene …

The rabbit has been recognized as a valuable model in various biomedical and biological
research fields because of its intermediate size and phylogenetic proximity to primates …

Purpose: Mutations in USH2A gene are responsible for the greatest proportion of the Usher
Syndrome (USH) population, among which more than 30% are frameshift mutations on exon …

Approximately 5% of all human cancers are attributable to human papillomavirus (HPV)
infections. HPV-associated diseases and cancers remain a substantial public health and …

Cystic Fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the
gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most …

The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we
developed an efficient system for generating genetically modified mice using maternal Cas9 …