When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …

Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …

Summary Type I Interferons (IFNs) are important cytokines for innate immunity against
viruses and cancer. Sixteen human type I IFN variants signal through the same cell-surface …

Type I interferons (IFNs) form a network of homologous cytokines that bind to a shared,
heterodimeric cell surface receptor and engage signaling pathways that activate innate and …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

For decades, type I IFNs have been considered indispensable and unique antiviral
mediators for the activation of rapid innate antiviral protection. However, the recent discovery …

Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10
signaling pathways that regulate intestinal inflammation, viral persistence and even tumor …