Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma
and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked …

Physiological ageing of the lung is associated with dilatation of alveoli, enlargement of
airspaces, decrease in exchange surface area and loss of supporting tissue for peripheral …

Administration of substances to laboratory animals requires careful consideration and
planning to optimize delivery of the agent to the animal while minimizing potential adverse …

A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was
facilitated by the European Respiratory Society (ERS) and the International Society for …

Asthma is a common inflammatory disease of the lungs. The prevalence of asthma is
increasing worldwide, and the tendency indicates that the number of asthma sufferers will …

The lungs are an attractive route for non-invasive drug delivery with advantages for both
systemic and local applications. Incorporating therapeutics with polymeric nanoparticles …

Rationale: Aerosol particle size influences the extent, distribution, and site of inhaled drug
deposition within the airways. Objectives: We hypothesized that targeting albuterol to …

Many companies are now prioritizing the development of dry powder inhalers (DPIs) above
pressurized formulations of asthma drugs. A well-designed DPI and an appropriate powder …

The pulmonary route is an interesting route for drug administration, both for effective local
therapy (asthma, chronic obstructive pulmonary disease or cystic fibrosis) and for the …

Life expectancy has risen sharply during the past century and is expected to continue to rise
in virtually all populations throughout the world. In the United States population, life …