细胞色素P450 (cytochrome P450， CYP) 家族的主要成员CYP3A 是人体中重要的药物代谢酶
之一。 CYP3A 包括4 种基因亚型(CYP3A4、 CYP3A5、 CYP3A7 和CYP3A43)， 参与人体60 …

At the outset of solid organ transplantation, genetic variation between donors and recipients
was recognized as a major player in mechanisms such as allograft tolerance and rejection …

Twenty-five years after its approval by the FDA and EMA, tacrolimus remains the
cornerstone of immunosuppressive treatment following solid organ transplantation [1, 2] …

The benefit of personalized medicine is that it allows the customization of drug therapy–
maximizing efficacy while avoiding side effects. Genetic polymorphisms are one of the major …

Background. The single-nucleotide polymorphism CYP3A5 rs776746 is related to a
reduction in the metabolizing activity of the CYP3A5 enzyme. People carrying at least one …

A validated CYP3A genotype classification system allows clustering patients into poor,
intermediate and extensive metabolizer phenotypes. However, substantial overlap exists …

Background and justification The strategy of the concentration-dose (C/D) approach and the
different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms …

Background: Tacrolimus is the most frequently used immunosuppressive drug for preventing
renal rejection. However, its use is hampered by its narrow therapeutic index and large intra …

Background Tacrolimus is a common immunosuppressive for transplantation. The enzyme
encoded by the CYP3A5 gene can regulate the metabolism of tacrolimus, and the …

Introduction Thanks to new generation sequencing (NGS) and expansion of HLA typing with
additional loci, it will be possible to increase the effectiveness of graft survival and to avoid …