Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Protease-targeted chimeras (PROTACs) are a new technology that is receiving much
attention in the treatment of diseases. The mechanism is to inhibit protein function by …

Mechanical signals play many roles in cell and developmental biology. Several
mechanotransduction pathways have been uncovered, but the mechanisms identified so far …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Microtubules play a major role in intracellular trafficking of vesicles in endocrine cells.
Detailed knowledge of microtubule organization and their relation to other cell constituents …

Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis.
The availability of free tubulin subunits affects polymerization dynamics and microtubule …

Microtubules control cell architecture by serving as a scaffold for intracellular transport,
signaling, and organelle positioning. Microtubules are intrinsically polarized, and their …

Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase
separation (LLPS) allows dynamic compartmentalization and regulation of biological …