Substrate pleiotropicity, a very acidic phosphorylation consensus sequence, and an
apparent uncontrolled activity, are the main features of CK2, a Ser/Thr protein kinase that is …

Dysregulation of microtubules and tubulin homeostasis has been linked to developmental
disorders, neurodegenerative diseases, and cancer. In general, both microtubule-stabilizing …

Centrosomes nucleate and organise the microtubule cytoskeleton in animal cells. These
membraneless organelles are key structures for tissue organisation, polarity and growth …

Microtubules form a highly dynamic filament network in all eukaryotic cells. Individual
microtubules grow by tubulin dimer subunit addition and frequently switch between phases …

A series of novel 3-amidoindole derivatives possessing 3, 4, 5-trimethoxylphenyl groups
were synthesized and evaluated for their antiproliferative and tubulin polymerization …

Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate
cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle …

Photothermal therapy (PTT) is emerging as an effective treatment modality for cancer due to
its noninvasive nature. However, the pro-inflammatory necrotic cell death during PTT limits …

The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises
a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and …

Simple Summary The genetic mechanisms that regulate biological processes, such as
skeletal muscle development and growth, or intramuscular fat deposition, have attracted …

Abstract A series of 3-(3′, 4′, 5′-trimethoxyphenyl)-4-substituted 1H-pyrazole and their
related 3-aryl-4-(3′, 4′, 5′-trimethoxyphenyl)-1-H-pyrazole regioisomeric derivatives …