Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

RNAs are underexploited targets for small molecule drugs or chemical probes of function.
This may be due, in part, to a fundamental lack of understanding of the types of small …

Current approaches used to identify protein-binding small molecules are not suited for
identifying small molecules that can bind emerging RNA drug targets. By docking small …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a key regulatory step in human
immunodeficiency virus-1 (HIV-1) transcription and thus in the reversal of HIV latency. By …

Rapid progress in genome sequencing technology has put us firmly into a postgenomic era.
A key challenge in biomedical research is harnessing genome sequence to fulfill the …

Recent efforts to identify RNA binding proteins in various organisms and cellular contexts
have yielded a large collection of proteins that are capable of RNA binding in the absence of …

MicroRNAs (miRNAs) help orchestrate cellular growth and survival through post-
transcriptional mechanisms. The dysregulation of miRNA biogenesis can lead to cellular …

The HIV-1 trans-activator protein Tat binds the trans-activation response element (TAR) to
facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the …

RNA is an immensely important target for small molecule therapeutics or chemical probes of
function. However, methods that identify, annotate, and optimize RNA-small molecule …

HIV-1 Tat hijacks the human superelongation complex (SEC) to promote proviral
transcription. Here we report the 5.9 Å structure of HIV-1 TAR in complex with HIV-1 Tat and …