Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

KRB Singh, V Nayak, J Singh, AK Singh, RP Singh - RSC advances, 2021 - pubs.rsc.org
To date, various reports have shown that metallic gold bhasma at the nanoscale form was
used as medicine as early as 2500 BC in India, China, and Egypt. Owing to their unique …

Traumatic brain injury: a disease process, not an event

BE Masel, DS DeWitt - Journal of neurotrauma, 2010 - liebertpub.com
Traumatic brain injury (TBI) is seen by the insurance industry and many health care
providers as an “event.” Once treated and provided with a brief period of rehabilitation, the …

Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson's disease

L Liu, Y Li, H Peng, R Liu, W Ji, Z Shi, J Shen, G Ma… - Science …, 2020 - science.org
The most critical problem in the treatment of neurodegenerative diseases is brain neuronal
protection, which can be overcome by clearing pathological substances and regulating the …

[HTML][HTML] Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

X Zhang, Y Zhang, R Li, L Zhu, B Fu, T Yan - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder,
which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed …

Metabolism and functions of glutathione in brain

R Dringen - Progress in neurobiology, 2000 - Elsevier
The tripeptide glutathione is the thiol compound present in the highest concentration in cells
of all organs. Glutathione has many physiological functions including its involvement in the …

Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment

B Halliwell - Drugs & aging, 2001 - Springer
Free radicals and other so-called 'reactive species' are constantly produced in the brain in
vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of …

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: implications for …

KA Conway, SJ Lee, JC Rochet… - Proceedings of the …, 2000 - National Acad Sciences
The Parkinson's disease (PD) substantia nigra is characterized by the presence of Lewy
bodies containing fibrillar α-synuclein. Early-onset PD has been linked to two point …

Molecular pathways of neurodegeneration in Parkinson's disease

TM Dawson, VL Dawson - Science, 2003 - science.org
Parkinson's disease (PD) is a complex disorder with many different causes, yet they may
intersect in common pathways, raising the possibility that neuroprotective agents may have …

Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct

KA Conway, JC Rochet, RM Bieganski, PT Lansbury Jr - Science, 2001 - science.org
The substantia nigra in Parkinson's disease (PD) is depleted of dopaminergic neurons and
contains fibrillar Lewy bodies comprising primarily α-synuclein. We screened a library to …

Embryo-derived stem cells: of mice and men

AG Smith - Annual review of cell and developmental biology, 2001 - annualreviews.org
▪ Abstract Mouse embryonic stem cells are continuous cell lines derived directly from the
fetal founder tissue of the preimplantation embryo. They can be expanded in culture while …