Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

H Duan, Q Zhang, J Liu, R Li, D Wang, W Peng… - Pharmacological …, 2021 - Elsevier
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of
cardiovascular diseases and is one of the predominant causes of death worldwide. Normal …

Network-based approach to prediction and population-based validation of in silico drug repurposing

F Cheng, RJ Desai, DE Handy, R Wang… - Nature …, 2018 - nature.com
Here we identify hundreds of new drug-disease associations for over 900 FDA-approved
drugs by quantifying the network proximity of disease genes and drug targets in the human …

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

L Liberale, F Montecucco, JC Tardif… - European heart …, 2020 - academic.oup.com
The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …

[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy

Q Xiao, X Li, Y Li, Z Wu, C Xu, Z Chen, W He - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

GJ Martinez, DS Celermajer, S Patel - Atherosclerosis, 2018 - Elsevier
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …

Anticytokine agents: targeting interleukin signaling pathways for the treatment of atherothrombosis

PM Ridker - Circulation research, 2019 - Am Heart Assoc
The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated
through both adaptive and innate immunity has led to the hypothesis that anticytokine …

Rational design of a double-locked photoacoustic probe for precise in vivo imaging of cathepsin B in atherosclerotic plaques

Y Ma, J Shang, L Liu, M Li, X Xu, H Cao… - Journal of the …, 2023 - ACS Publications
Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as
heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine …

Inflammation as a therapeutic target in atherosclerosis

MT Nguyen, S Fernando, N Schwarz, JTM Tan… - Journal of clinical …, 2019 - mdpi.com
Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …