Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
Targeting early atherosclerosis: a focus on oxidative stress and inflammation
P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …
Rational design of a double-locked photoacoustic probe for precise in vivo imaging of cathepsin B in atherosclerotic plaques
Y Ma, J Shang, L Liu, M Li, X Xu, H Cao… - Journal of the …, 2023 - ACS Publications
Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as
heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine …
heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine …
Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis
H Duan, Q Zhang, J Liu, R Li, D Wang, W Peng… - Pharmacological …, 2021 - Elsevier
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of
cardiovascular diseases and is one of the predominant causes of death worldwide. Normal …
cardiovascular diseases and is one of the predominant causes of death worldwide. Normal …
Network-based approach to prediction and population-based validation of in silico drug repurposing
Here we identify hundreds of new drug-disease associations for over 900 FDA-approved
drugs by quantifying the network proximity of disease genes and drug targets in the human …
drugs by quantifying the network proximity of disease genes and drug targets in the human …
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
L Liberale, F Montecucco, JC Tardif… - European heart …, 2020 - academic.oup.com
The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …
related cardiovascular (CV) diseases in the coming decades that demands a deeper …
[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …
inflammation, and some autoimmune diseases are closely linked to the immune system …
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …
Anticytokine agents: targeting interleukin signaling pathways for the treatment of atherothrombosis
PM Ridker - Circulation research, 2019 - Am Heart Assoc
The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated
through both adaptive and innate immunity has led to the hypothesis that anticytokine …
through both adaptive and innate immunity has led to the hypothesis that anticytokine …
Inflammation as a therapeutic target in atherosclerosis
MT Nguyen, S Fernando, N Schwarz, JTM Tan… - Journal of clinical …, 2019 - mdpi.com
Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …