Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

FTY720 is a potent immunomodulator drug that inhibits the egress of lymphocytes from
secondary lymphoid tissues and thymus. FTY720 is phosphorylated in vivo by sphingosine …

Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived
prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties …

It is now established that prostanoids play important roles in many cellular responses and
pathophysiologic processes including modulation of the inflammatory reaction, erosion of …

NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation
of 15 (S)-hydroxyl group of prostaglandins and lipoxins resulting in the formation of 15-keto …

Isatin is a versatile compound with a diversity of effects. We designed to investigate the
inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-γ-induced expression …

A drawback of extensive coxib use for antitumor purposes is the risk of life-threatening side
effects that are thought to be a class effect and probably due to the resulting imbalance of …

Gallic acid (GA) induces apoptosis in various cancer cell lines. In this study, we investigated
the apoptotic activity induced by GA on chronic myeloid leukemia (CML) cell line-K562 and …

UV-irradiated skin and UV-induced tumors overexpress the inducible isoform of
cyclooxygenase-2 (Cox-2), and Cox-2 inhibition reduces photocarcinogenesis. To evaluate …