Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Simple Summary Significant gender disparities have been highlighted in the incidence,
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …

Background Effective treatments for patients with primary biliary cholangitis are limited.
Seladelpar, a peroxisome proliferator–activated receptor delta agonist, has potential …

Background & Aims Approaches to risk stratification for patients with primary biliary cirrhosis
(PBC) are limited, single-center based, and often dichotomous. We aimed to develop and …

Background & Aims We examined the efficacy and safety of seladelpar, a selective
peroxisome proliferator-activated receptor-delta agonist, in adults with primary biliary …

Abstract Background & Aims Primary biliary cholangitis (PBC) can result in life‐altering
cholestatic pruritus and fatigue, but treatment options are limited. Seladelpar, a peroxisome …

Primary Biliary Cholangitis (PBC) is a rare autoimmune disease of the liver, affecting mostly
females. There is evidence that epigenetic changes have a pathogenic role in PBC …

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are two chronic
cholestatic liver diseases affecting bile ducts that may progress to biliary cirrhosis. In the past …

Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an
autoimmune liver disease that mostly affects women. A progressive disorder in the …

Cholestasis is a major pathological manifestation, often resulting in detrimental liver
conditions, which occurs in a variety of indications collectively termed cholestatic liver …