Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well
as profound psychological and mystical experiences. A grouping of interconnected brain …

Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

Recent findings suggesting the potential transdiagnostic efficacy of psychedelic-assisted
therapy have fostered the need to deepen our understanding of psychedelic brain action …

Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …

Psychedelic drugs such as psilocybin have shown substantial promise for the treatment of
several psychiatric conditions including mood and addictive disorders. They also have the …

Our hominin ancestors inevitably encountered and likely ingested psychedelic mushrooms
throughout their evolutionary history. This assertion is supported by current understanding …

Clinical research into serotonergic psychedelics is expanding rapidly, showing promising
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …

The serotonergic classical psychedelics include compounds that primarily activate the
brain's serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca) …

The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …