Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and
altered connectivity in brain networks. While measures of amyloid accumulation and …

Brain aging is a natural process that involves structural and functional changes that lead to
cognitive decline, even in healthy subjects. This detriment has been associated with NMDA …

Background This is an exploratory study using multimodal magnetic resonance imaging
(MRI) to interrogate the brain of rats with type 2 diabetes (T2DM) as compared to controls. It …

Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of
control over intake and the development of a negative emotional state when access to …

Background Alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonists have been
developed to treat schizophrenia but failed in clinical trials due to rapid desensitization …

The understanding of human and non-human microstructural brain alterations in the course
of neurodegenerative diseases has substantially improved by the non-invasive magnetic …

Learning can be categorized into cue-instructed and spontaneous learning types; however,
so far, there is no detailed comparative analysis of specific brain pathways involved in these …

Microtus ochrogaster, the prairie vole, has become a valuable rodent model to study
complex social behaviors, including enduring social bonding. Previous studies have related …

The strongest genetic risk factor for Alzheimer's disease (AD) is the Ɛ4 allele of
apolipoprotein E (ApoE ɛ4). A high fat diet also adds to the risk of dementia and AD. In …

Mounting evidence suggests that cognitive deficits associated with various neurological
disorders may arise in part from a small population of dysregulated adult-born neurons in …