Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …

Progressive retinal ganglion cells (RGCs) death that triggered by retinal ischemia
reperfusion (IR), leads to irreversible visual impairment and blindness, but our knowledge of …

Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …

Retinal ischemia is involved in the occurrence and development of various eye diseases,
including glaucoma, diabetic retinopathy, and central retinal artery occlusion. To the best of …

Background The aim of this study was to establish a complete retinal cell atlas of ischemia–
reperfusion injury by single-cell RNA sequencing, and to explore the underlying mechanism …

Introduction Clinical trials demonstrated that co-targeting angiopoietin-2 (Ang-2) and
vascular endothelial growth factor (VEGF-A) with faricimab controls anatomic outcomes and …

Cerebral ischemia is a devastating condition that results in impaired blood flow in the brain
leading to acute brain injury. As the most common form of stroke, occlusion of cerebral …

Retinal ischemia–reperfusion (RIR) injury caused by high intraocular pressure (IOP) is an
important risk factor contributing to retinal ganglion cell (RGC) death, eventually causing …

Abstract The enzyme arginase 1 (A1) hydrolyzes the amino acid arginine to form L-ornithine
and urea. Ornithine is further converted to polyamines by the ornithine decarboxylase (ODC) …