Conspectus Peptides are essential components of living systems and contribute to critical
biological processes, such as cell proliferation, immune defense, tumor formation, and …

Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine.
They are targets of many drugs for various conditions, including treatment of hypertension …

Morphine and fentanyl are among the most used opioid drugs that confer analgesia and
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …

Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …

The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management
without addiction, and biased signaling through particular pathways of KOR may be key to …

Abstract Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain's
ability to control sleep-wake cycles. Current therapies are limited to the management of …

Achieving effective pain management is one of the major challenges associated with
modern day medicine. Opioids, such as morphine, have been the reference treatment for …

G-protein coupled receptors (GPCRs) are membrane proteins that convey extracellular
signals to the cellular milieu. They represent a target for more than 30% of currently …

Orthomyxo-and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own
transcription in a process called “cap snatching.” We report that RNA modification of the cap …

The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …