Next-generation sequencing: insights to advance clinical investigations of the microbiome
CR Wensel, JL Pluznick, SL Salzberg… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …
human microbiome by allowing for the discovery and characterization of unculturable …
Next generation sequencing of SARS-CoV-2 genomes: challenges, applications and opportunities
Various next generation sequencing (NGS) based strategies have been successfully used in
the recent past for tracing origins and understanding the evolution of infectious agents …
the recent past for tracing origins and understanding the evolution of infectious agents …
Adeno-associated virus type 2 in US children with acute severe hepatitis
V Servellita, A Sotomayor Gonzalez, DM Lamson… - Nature, 2023 - nature.com
As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have
been reported from 35 countries, including the USA,. Previous studies have found human …
been reported from 35 countries, including the USA,. Previous studies have found human …
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids
We developed a metagenomic next-generation sequencing (mNGS) test using cell-free DNA
from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids …
from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids …
Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota
In this paper we compared taxonomic results obtained by metataxonomics (16S rRNA gene
sequencing) and metagenomics (whole shotgun metagenomic sequencing) to investigate …
sequencing) and metagenomics (whole shotgun metagenomic sequencing) to investigate …
[HTML][HTML] Massively multiplexed nucleic acid detection with Cas13
The great majority of globally circulating pathogens go undetected, undermining patient care
and hindering outbreak preparedness and response. To enable routine surveillance and …
and hindering outbreak preparedness and response. To enable routine surveillance and …
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection
The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …
New opportunities in plant microbiome engineering for increasing agricultural sustainability under stressful conditions
Plant microbiome (or phytomicrobiome) engineering (PME) is an anticipated untapped
alternative strategy that could be exploited for plant growth, health and productivity under …
alternative strategy that could be exploited for plant growth, health and productivity under …
Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution
Background Species-level genetic characterization of complex bacterial communities has
important clinical applications in both diagnosis and treatment. Amplicon sequencing of the …
important clinical applications in both diagnosis and treatment. Amplicon sequencing of the …
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with> 365,000 cases in …
syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with> 365,000 cases in …