Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury
V Kumar - Frontiers in immunology, 2020 - frontiersin.org
The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …
epithelial surface in direct contact with the external environment. It also serves as a crucial …
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
C Krishna, RG DiNatale, F Kuo, RM Srivastava… - Cancer cell, 2021 - cell.com
Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …
Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in …
M Nakano, K Kubota, E Kobayashi, TS Chikenji… - Scientific reports, 2020 - nature.com
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …
Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice
N Lohmann, L Schirmer, P Atallah, E Wandel… - Science translational …, 2017 - science.org
Excessive production of inflammatory chemokines can cause chronic inflammation and thus
impair cutaneous wound healing. Capturing chemokine signals using wound dressing …
impair cutaneous wound healing. Capturing chemokine signals using wound dressing …
Genetically manipulated mouse models of lung disease: potential and pitfalls
RM Baron, AJS Choi, CA Owen… - American Journal of …, 2012 - journals.physiology.org
Gene targeting in mice (transgenic and knockout) has provided investigators with an
unparalleled armamentarium in recent decades to dissect the cellular and molecular basis …
unparalleled armamentarium in recent decades to dissect the cellular and molecular basis …
ATP evokes Ca2+ responses and CXCL5 secretion via P2X4 receptor activation in human monocyte-derived macrophages
Leukocytes sense extracellular ATP, a danger-associated molecular pattern, released
during cellular stress and death, via activation of cell surface P2X and P2Y receptors. Here …
during cellular stress and death, via activation of cell surface P2X and P2Y receptors. Here …
[HTML][HTML] Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma
Background The presence of a highly immunosuppressive tumor microenvironment has
limited the success of immune checkpoint therapy (ICT). Immune suppressing myeloid cells …
limited the success of immune checkpoint therapy (ICT). Immune suppressing myeloid cells …
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study
Functional immune responses are increasingly important for clinical studies, providing in
depth biomarker information to assess immunotherapy or vaccination. Incorporating …
depth biomarker information to assess immunotherapy or vaccination. Incorporating …
IL-17A promotes the exacerbation of IL-33–induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice
N Mizutani, T Nabe, S Yoshino - The Journal of Immunology, 2014 - journals.aai.org
Neutrophilic airway inflammation is a hallmark of patients with severe asthma. Although we
have reported that both IL-33 and IL-17A contributed to IgE-mediated neutrophilic …
have reported that both IL-33 and IL-17A contributed to IgE-mediated neutrophilic …
Role of CXCL5 in regulating chemotaxis of innate and adaptive leukocytes in infected lungs upon pulmonary influenza infection
L Guo, N Li, Z Yang, H Li, H Zheng, J Yang… - Frontiers in …, 2021 - frontiersin.org
Respirovirus such as influenza virus infection induces pulmonary anti-viral immune
response, orchestration of innate and adaptive immunity restrain viral infection, otherwise …
response, orchestration of innate and adaptive immunity restrain viral infection, otherwise …