Looping out of control: R-loops in transcription-replication conflict
Transcription-replication conflict is a major cause of replication stress that arises when
replication forks collide with the transcription machinery. Replication fork stalling at sites of …
replication forks collide with the transcription machinery. Replication fork stalling at sites of …
An updated perspective on the polymerase division of labor during eukaryotic DNA replication
TA Guilliam, JTP Yeeles - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
In eukaryotes three DNA polymerases (Pols), α, δ, and ε, are tasked with bulk DNA synthesis
of nascent strands during genome duplication. Most evidence supports a model where Pol α …
of nascent strands during genome duplication. Most evidence supports a model where Pol α …
The interplay of RNA: DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions
R-loops are a major source of genome instability associated with transcription-induced
replication stress. However, how R-loops inherently impact replication fork progression is …
replication stress. However, how R-loops inherently impact replication fork progression is …
Synergism between CMG helicase and leading strand DNA polymerase at replication fork
Z Xu, J Feng, D Yu, Y Huo, X Ma, WH Lam, Z Liu… - Nature …, 2023 - nature.com
The replisome that replicates the eukaryotic genome consists of at least three engines: the
Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and …
Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and …
The fork protection complex recruits FACT to reorganize nucleosomes during replication
Chromosome replication depends on efficient removal of nucleosomes by accessory factors
to ensure rapid access to genomic information. Here, we show this process requires …
to ensure rapid access to genomic information. Here, we show this process requires …
Revisiting the BRCA-pathway through the lens of replication gap suppression:“Gaps determine therapy response in BRCA mutant cancer”
SB Cantor - DNA repair, 2021 - Elsevier
The toxic lesion emanating from chemotherapy that targets the DNA was initially debated,
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
AW McClure, JFX Diffley - Elife, 2021 - elifesciences.org
The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell
response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding …
response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding …
The TIMELESS effort for timely DNA replication and protection
JA Patel, H Kim - Cellular and Molecular Life Sciences, 2023 - Springer
Accurate replication of the genome is fundamental to cellular survival and tumor prevention.
The DNA replication fork is vulnerable to DNA lesions and damages that impair replisome …
The DNA replication fork is vulnerable to DNA lesions and damages that impair replisome …
Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks …
Y Benureau, C Pouvelle, P Dupaigne… - Nucleic Acids …, 2022 - academic.oup.com
DNA lesions in S phase threaten genome stability. The DNA damage tolerance (DDT)
pathways overcome these obstacles and allow completion of DNA synthesis by the use of …
pathways overcome these obstacles and allow completion of DNA synthesis by the use of …
Toxic R-loops: Cause or consequence of replication stress?
Transcription-replication conflicts (TRCs) represent a potential source of endogenous
replication stress (RS) and genomic instability in eukaryotic cells but the mechanisms that …
replication stress (RS) and genomic instability in eukaryotic cells but the mechanisms that …