Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …

Androgens affect the cerebral vasculature and may contribute to sex differences in
cerebrovascular diseases. Men are at a greater risk for stroke and vascular contributions to …

Background: High midlife and late-life adiposity may increase risk for dementia. Late-life
decrease in body mass index (BMI) or body weight within several years of a dementia …

This study assessed the extent to which high fat diet (HFD)-induced β-amyloid accumulation
and cognitive decline in APP/PSEN1 mice are reversible through control of fat intake. Ten …

That the brain is involved in the pathogenesis and perpetuation of obesity is broadly self-
intuitive, but traditional evaluation of this relationship has focused on psychological and …

Background Middle age obesity is recognized as a risk factor for Alzheimer's disease (AD)
although a mechanistic linkage remains unclear. Based upon the fact that obese adipose …

Alzheimer's disease (AD) is an age-related progressive dementia, which is increasing in
prevalence world-wide. Typically affecting short-term memory at onset, this devastating …

The baby boom generation is approaching the age of greatest risk for cognitive impairment
and dementia. There is growing interest in strategies to modify the environment in midlife to …

Alzheimer's disease (AD) is becoming an increasingly heavy burden on the society of
developed countries, and physicians now face the challenge of providing efficient treatment …

Objective: Higher late life body mass index (BMI) is unrelated to or even predicts lower risk
of dementia in late life, a phenomenon that may be explained by reverse causation due to …