Pancreatic cancer is the world's fourth largest causative factor of mortality with a five year of
survival rate. Poor definitive diagnosis can be ascribed to both problematic early detections …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a
poor prognosis. Here, we successfully established organoid lines derived from intrahepatic …

Clinical oncology is being revolutionized by the increasing use of molecularly targeted
therapies. This paradigm holds great promise for improving cancer treatment; however …

Background Pancreatic cancer (PC) is a highly lethal disease with few effective treatment
options. Over the past few decades, many anti‐cancer therapies have been tested in the …

Pancreatic cancer is one of the most lethal malignancies and is associated with a poor
prognosis. Surgery is considered the only potential curative treatment for pancreatic cancer …

Background and Aim: Pancreatic cancer is one of the most fatal cancers. Cytotoxic
chemotherapy remains the mainstream treatment for unresectable pancreatic cancer. This …

Pancreatic ductal adenocarcinoma (PDAC) is among the most deadly solid tumours. This is
due to a generally late-stage diagnosis of a primarily treatment-refractory disease. Several …

Cancer is one of the leading causes of death worldwide, and conventional cancer therapies
such as surgery, chemotherapy, and radiotherapy do not address the underlying molecular …

Pancreatic ribonuclease (RNase) is a secreted enzyme critical for host defense. We discover
an intrinsic RNase function, serving as a ligand for epidermal growth factor receptor (EGFR) …