Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Thanks to the unbiased exploration of genomic variants at large scale, hundreds of
thousands of disease-associated loci have been uncovered. In parallel, network-based …

Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …

Respiratory viral infections are the most important triggers of asthma exacerbations.
Rhinovirus (RV), the common cold virus, is clearly the most prevalent pathogen constantly …

The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted …

To identify candidate causal genes of asthma, we performed a genome-wide association
study (GWAS) in UK Biobank on a broad asthma definition (n= 56,167 asthma cases and …