Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors

K Welsch, J Holstein, A Laurence… - European journal of …, 2017 - Wiley Online Library
For most inflammatory skin diseases topical glucocorticosteroids and traditional oral
immunosuppressive drugs remain the principle treatment choices, but this has started to …

[HTML][HTML] Atopic dermatitis in animals and people: an update and comparative review

R Marsella, A De Benedetto - Veterinary sciences, 2017 - mdpi.com
Atopic dermatitis is an extremely common, pruritic, and frustrating disease to treat in both
people and animals. Atopic dermatitis is multifactorial and results from complex interactions …

Update on pathogenesis, diagnosis, and treatment of atopic dermatitis in dogs

TJ Nuttall, R Marsella, MR Rosenbaum… - Journal of the …, 2019 - Am Vet Med Assoc
Improved understanding of the pathogenesis of atopic dermatitis in dogs has led to more
effective treatment plans, including skin barrier repair and new targeted treatments for …

Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation

MT Walker, JE Green, RP Ferrie, AM Queener… - Journal of Allergy and …, 2018 - Elsevier
Background Mechanisms for the development of food allergy in neonates are unknown but
clearly linked in patient populations to a genetic predisposition to skin barrier defects …

[HTML][HTML] Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model

JH Park, JY Choi, DJ Son, EK Park, MJ Song… - International journal of …, 2017 - mdpi.com
Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-
dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic …

Insights into atopic dermatitis gained from genetically defined mouse models

S Nakajima, T Nomura, J Common… - Journal of Allergy and …, 2019 - Elsevier
Atopic dermatitis (AD) is characterized by severe pruritus and recurrent eczema with a
chronic disease course. Impaired skin barrier function, hyperactivated TH 2 cell–type …

Molecular aspects of allergens in atopic dermatitis

R Campana, S Dzoro, I Mittermann… - Current opinion in …, 2017 - journals.lww.com
Molecular allergology allows for dissection of the pathomechanisms of atopic dermatitis,
provides new forms of allergy diagnosis for identification of disease-causing allergens, and …

Genetic determinants of paediatric food allergy: a systematic review

NHA Suaini, Y Wang, VX Soriano, DJ Martino… - Allergy, 2019 - Wiley Online Library
Background The genetic determinants of food allergy have not been systematically
reviewed. We therefore systematically reviewed the literature on the genetic basis of food …

[HTML][HTML] Regulatory T cells suppress inflammation and blistering in pemphigoid diseases

K Bieber, S Sun, M Witte, A Kasprick… - Frontiers in …, 2017 - frontiersin.org
Regulatory T cells (Tregs) are well known for their modulatory functions in adaptive
immunity. Through regulation of T cell functions, Tregs have also been demonstrated to …

[HTML][HTML] Translational relevance of mouse models of atopic dermatitis

J Choi, N Sutaria, YS Roh, Z Bordeaux… - Journal of clinical …, 2021 - mdpi.com
The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate
selection of a mouse model because no single murine model completely recapitulates all …