Cutaneous filarioid nematodes of dogs in the United States: Are they emerging, neglected, or underdiagnosed parasites?

J Gruntmeir, M Kelly, RAN Ramos… - Frontiers in Veterinary …, 2023 - frontiersin.org
Filarioid nematodes, which are vector-borne parasites of cosmopolitan distribution, of dogs
are medically important. They are represented by species in which microfilariae were found …

Relative diagnostic accuracy of point-of-care tests to rule-in Dirofilaria immitis infection in clinically suspect dogs: A systematic review and meta-analysis

PJ Atkinson, R O'Handley, T Nielsen… - Preventive Veterinary …, 2023 - Elsevier
Canine heartworm, Dirofilaria immitis, can cause severe disease and sometimes death of
the host. Associated clinical signs, lack of preventative usage and regional endemicity are …

Nationwide molecular survey of Dirofilaria immitis and Dirofilaria repens in companion dogs and cats, United States of America

R Smith, DFB Murillo, K Chenoweth, S Barua… - Parasites & …, 2022 - Springer
Abstract Background Heartworms, Dirofilaria immitis, are known to be widespread in dogs
and cats in the USA, but there have been no country-wide prevalence studies performed to …

Pre-treatment of canine plasma with heat, rather than acid, efficiently enhances Dirofilaria immitis antigen detection

DFB Murillo, C Wang - Parasites & Vectors, 2023 - Springer
Background The dissociation of antigen-antibody complexes has been utilized to enhance
the accuracy of serological tests for infectious diseases, including Dirofilaria immitis …

Increasing temperature denatures canine IgG reducing its ability to inhibit heartworm antigen detection

JM Gruntmeir, JR Abbott, PE Kima, MT Long… - Parasites & …, 2023 - Springer
Background Immune complexing of target antigen to high affinity host antibody is recognized
to impact the sensitivity of commercial heartworm antigen tests. Published information …

Optimizing heartworm diagnosis in dogs using multiple test combinations

JN Lane, A Litster, SE Little, JY Rodriguez… - Parasites & …, 2021 - Springer
Background Various heartworm (HW) diagnostic testing modalities detect products of, or
reactions to, different life cycle stages of Dirofilaria immitis. Microfilariae (Mf) can be directly …

Selection of new diagnostic markers for Dirofilaria repens infections with the use of phage display technology

M Pękacz, K Basałaj, A Kalinowska, M Klockiewicz… - Scientific Reports, 2022 - nature.com
Dirofilaria repens is a parasitic nematode causing vector-borne disease (dirofilariasis),
considered an emerging problem in veterinary and human medicine. Although main hosts …

Improved Antigen Detection of Male-Only Dirofilaria immitis Infections in Canine Serum after Heat Treatment for Immune Complex Dissociation

J Gruntmeir, M Long, B Blagburn, H Walden - Parasitologia, 2023 - mdpi.com
Since the mid-1990s, male-only heartworm infections have been considered undetectable
using antigen tests based on experimental studies. Results from those studies are in …

Multiple diagnostic tests demonstrate an increased risk of canine heartworm disease in northern Queensland, Australia

JL Panetta, NED Calvani, B Orr, AG Nicoletti… - Parasites & …, 2021 - Springer
Abstract Background Canine heartworm (Dirofilaria immitis) is a life-threatening infection of
dogs with a global distribution. Information on the prevalence of D. immitis and associated …

Heat Treatment Augments Antigen Detection of Dirofilaria immitis in Apparently Healthy Companion Dogs (3.8% to 7.3%): Insights from a Large-Scale Nationwide …

DF Barrantes Murillo, A Moye, C Wang - Pathogens, 2024 - mdpi.com
Background: Heartworm disease (HWD) is a vector-borne disease caused by the filarial
nematode Dirofilaria immitis. Low antigen levels caused by immune complex formation …