Alternative splicing in prostate cancer progression and therapeutic resistance

C Rawat, HV Heemers - Oncogene, 2024 - nature.com
Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men.
CaP mortality results from diverse molecular mechanisms that mediate resistance to the …

Deciphering the role of alternative splicing in neoplastic diseases for immune-oncological therapies

M Bauer, CM Schöbel, C Wickenhauser… - Frontiers in …, 2024 - frontiersin.org
Alternative splicing (AS) is an important molecular biological mechanism regulated by
complex mechanisms involving a plethora of cis and trans-acting elements. Furthermore, AS …

Simultaneous detection of 5-methylcytosine and 5-hydroxymethylcytosine at specific genomic loci by engineered deaminase-assisted sequencing

NB Xie, M Wang, TT Ji, X Guo, FY Gang, Y Hao… - Chemical …, 2024 - pubs.rsc.org
Cytosine modifications, particularly 5-methylcytosine (5mC) and 5-hydroxymethylcytosine
(5hmC), play crucial roles in numerous biological processes. Current analytical methods are …

The Oncogenic Role and Prognostic Value of PXDN in Human Stomach Adenocarcinoma

Y Tian, S Qiu, S Yang, Y Jiang, H Hu, C Yang, J Cao… - 2023 - researchsquare.com
Stomach adenocarcinoma (STAD), recognized for its prevalence and poor prognostic
profile, necessitates the urgent identification of novel therapeutic targets. Peroxidasin …