Head and neck cancer (head and neck squamous cell carcinoma (HNSCC)) is a devastating
disease. Patients require intensive treatment that is often disfiguring and debilitating. Those …

The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …

DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …

In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …

Capillary and nano liquid chromatography coupled to mass spectrometry has recently
become one of the primary analytical techniques in many science areas of maior interest …

Cigarette smoking is an established risk factor for oral cancer. The health effects of e-
cigarettes are still under investigation but may disturb oral cavity homeostasis and cause …

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human …

Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons
(PAH) is recognized to play an important role in the development of oral/head and neck …

While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small
fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which …