Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Leishmaniasis diagnosis: an update on the use of parasitological, immunological and molecular methods

S Thakur, J Joshi, S Kaur - Journal of Parasitic Diseases, 2020 - Springer
Diagnosis of leishmaniasis has always been a major challenge as its clinical features
resemble some other commonly occurring diseases such as tuberculosis, typhoid, and …

Role of cytokines in experimental and human visceral leishmaniasis

M Samant, U Sahu, SC Pandey… - Frontiers in cellular and …, 2021 - frontiersin.org
Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Diagnosis of visceral leishmaniasis: developments over the last decade

G Srividya, A Kulshrestha, R Singh, P Salotra - Parasitology research, 2012 - Springer
Diagnostic parameters for visceral leishmaniasis (VL), a potentially fatal parasitic disease
caused by Leishmania donovani, have been redefined in the last decade with the …

[HTML][HTML] Visceral leishmaniasis: a global overview

RG Wamai, J Kahn, J McGloin, G Ziaggi - Journal of Global Health …, 2020 - e-jghs.org
The leishmaniases are protozoan infections that are among the neglected tropical diseases
(NTDs). Over one billion people are at risk of these diseases in virtually all continents. These …

A novel mechanism for an old drug: amphotericin B in the treatment of visceral leishmaniasis

A Chattopadhyay, M Jafurulla - Biochemical and biophysical research …, 2011 - Elsevier
Visceral leishmaniasis (VL) is caused by various species of the genus Leishmania.
Internalization of Leishmania into host cells is facilitated by a large number of receptors, and …

Developments in diagnosis of visceral leishmaniasis in the elimination era

OP Singh, S Sundar - Journal of parasitology research, 2015 - Wiley Online Library
Visceral leishmaniasis (VL) is the most devastating parasitic infection worldwide causing
high morbidity and mortality. Clinical presentation of VL ranges from asymptomatic or …

Risk factors for adverse prognosis and death in American visceral leishmaniasis: a meta-analysis

VS Belo, CJ Struchiner, DS Barbosa… - PLoS neglected …, 2014 - journals.plos.org
Background In the current context of high fatality rates associated with American visceral
leishmaniasis (VL), the appropriate use of prognostic factors to identify patients at higher risk …

Nanotechnology-based strategies in parasitic disease management: from prevention to diagnosis and treatment

R Tiwari, RP Gupta, VK Singh, A Kumar, Rajneesh… - ACS …, 2023 - ACS Publications
Parasitic infections are a major global health issue causing significant mortality and
morbidity. Despite substantial advances in the diagnostics and treatment of these diseases …

Evaluating drug resistance in visceral leishmaniasis: the challenges

S Hendrickx, PJ Guerin, G Caljon, SL Croft, L Maes - Parasitology, 2018 - cambridge.org
For decades antimonials were the drugs of choice for the treatment of visceral leishmaniasis
(VL), but the recent emergence of resistance has made them redundant as first-line therapy …