Genetic variants in preeclampsia: Lessons from studies in Latin-American populations

RT Michita, VL Kaminski, JAB Chies - Frontiers in Physiology, 2018 - frontiersin.org
Placental vascularization is a tightly regulated physiological process in which the maternal
immune system plays a fundamental role. Vascularization of the maternal-placental interface …

Progress in research on biomarkers of gestational diabetes mellitus and preeclampsia

Y Liu, DY Li, A Bolatai, N Wu - Diabetes, Metabolic Syndrome and …, 2023 - Taylor & Francis
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common complications in
pregnancy, with incidence rates of 1–5% and 9.4%, respectively, in China. Both these …

Association analysis of polymorphisms in LEP (rs7799039 and rs2167270) and LEPR (rs1137101) gene towards the development of type 2 diabetes in North Indian …

V Bains, H Kaur, B Badaruddoza - Gene, 2020 - Elsevier
Objectives Obesity is a major risk factor in aetiology of type 2 diabetes mellitus (T2DM).
Leptin (LEP) is an anti-obesity hormone which regulates food intake, energy expenditure …

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

DM Duan, JY Jhang, S Wu, MS Teng… - Molecular genetics & …, 2020 - Wiley Online Library
Background Obesity has become the main health issue in developed countries as it impacts
life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The …

Candidate gene and genome-wide association studies for circulating leptin levels reveal population and sex-specific associations in high cardiovascular risk …

C Ortega-Azorín, O Coltell, EM Asensio, JV Sorlí… - Nutrients, 2019 - mdpi.com
Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance.
However, the genes and gene variants that influence its plasma levels are still not well …

[HTML][HTML] Leptin receptor gene polymorphisms in kidney transplant patients with post-transplant diabetes mellitus treated with tacrolimus

V Dziedziejko, K Safranow, M Kijko-Nowak… - International …, 2023 - Elsevier
Post-transplant diabetes mellitus (PTDM) is a metabolic complication that often occurs after
kidney transplantation. Factors that increase the risk of this complication are currently being …

The role of maternal DNA methylation in pregnancies complicated by gestational diabetes

S Dias, T Willmer, S Adam, C Pheiffer - Frontiers in Clinical Diabetes …, 2022 - frontiersin.org
Diabetes in pregnancy is associated with adverse pregnancy outcomes and poses a serious
threat to the health of mother and child. Although the pathophysiological mechanisms that …

The association between leptin and diabetes: A meta‐analysis

XY Wu, HB Song, JW Wang - Journal of Obstetrics and …, 2024 - Wiley Online Library
Purpose The study object was to determine the relationship between leptin and diabetes.
Methods We searched for the literature on the relationship between leptin and diabetes from …

Association between chemerin rs17173608 and rs4721 gene polymorphisms and gestational diabetes mellitus in Iranian pregnant women

Z Hasanvand, A Sadeghi, MR Rezvanfar, MT Goodarzi… - Gene, 2018 - Elsevier
Gestational diabetes mellitus (GDM) is defined as hyperglycemia detected during pregnancy
and its risk is increased with obesity. Chemerin, an adipokine, has been proposed as …

[HTML][HTML] LEP G2548A polymorphism is associated with increased serum leptin and insulin resistance among T2DM Malaysian patients

LA Ali, K Jemon, N Ab Latif, SA Bakar, SSS Alwi - BioMedicine, 2022 - ncbi.nlm.nih.gov
Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome that is rapidly
increasing across the world, especially in Malaysia. Leptin plays a vital role in the regulation …