The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Exosomes are extracellular vesicles released upon fusion of multivesicular bodies (MVBs)
with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) during the …

Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to
restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Autophagy is a central mechanism by which hepatocytes catabolize lipid droplets (LDs).
Currently, the regulatory mechanisms that control this important process are poorly defined …

Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

Mucosal immunity protects a host from intestinal inflammation and infection and is
profoundly influenced by symbiotic bacteria. Here we report that in mice symbiotic bacteria …

Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and
there are 66 Rab genes in the human genome. They alternate between GTP-and GDP …