One in 4 Americans> 40 years of age takes a statin to reduce the risk of myocardial
infarction, ischemic stroke, and other complications of atherosclerotic disease. The most …

Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality. Statins are
the first-choice therapy for dyslipidemias and are considered the cornerstone of …

Chronic plaque psoriasis is an immune-mediated inflammatory skin disease that is strongly
associated with the clinical features of the metabolic syndrome (MetS), including abdominal …

Introduction Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lower
cholesterol synthesis in patients with hypercholesterolemia. Increased statin exposure is an …

Colchicine is an ancient medication that is currently approved for the treatment of gout and
FMF. However, colchicine has a wide range of anti-inflammatory activities, and studies …

The interindividual genetic variations in drug metabolizing enzymes and transporters
influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision …

Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …

The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

A n D GUID eLIneS affordability may often dictate which medications may be prescribed.
Patients who have exhausted prescription drug coverage or who are uninsured may require …