Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …

Network dynamics have been proposed as a mechanistic substrate for the information
transfer across cortical and hippocampal circuits. However, little is known about the …

Extended wakefulness is associated with reduced performance and the build-up of sleep
pressure. In the cortex, this manifests as changes in network activity. These changes show …

Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …

Over more than a century of research has established the fact that sleep benefits the
retention of memory. In this review we aim to comprehensively cover the field of “sleep and …

Independent evidence associates β-amyloid pathology with both non-rapid eye movement
(NREM) sleep disruption and memory impairment in older adults. However, whether the …

A common observation in EEG research is that consciousness vanishes with the
appearance of delta (1–4 Hz) waves, particularly when those waves are high amplitude …

Summary Ultra-slow,∼ 0.1-Hz variations in the oxygenation level of brain blood are widely
used as an fMRI-based surrogate of" resting-state" neuronal activity. The temporal …

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