Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

It has long been understood that many of the same manipulations that increase longevity in
Caenorhabditis elegans also increase resistance to various acute stressors, and vice-versa; …

Evolutionarily conserved mechanisms that control aging are predicted to have
prereproductive functions in order to be subject to natural selection. Genes that are essential …

Improvements in health care have increased human life expectancy in recent decades, and
the elderly population is thus increasing in most developed countries. Unfortunately this still …

Reduced insulin/insulin‐like growth factor (IGF) signaling may be a natural way for the
reduction of dietary nutrients to extend lifespan. While evidence challenging this hypothesis …

Interventions that slow aging and prevent chronic disease may come from an understanding
of how dietary restriction (DR) increases lifespan. Mechanisms proposed to mediate DR …

In 1935, Clive McCay and colleagues reported that decreasing the food intake of rats
extends their life. This finding has been confirmed many times using rat and mouse models …

Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic
intermediary metabolism, suggesting that the major metabolic pathways are probably …

Unlike the soma, which ages during the lifespan of multicellular organisms, the germ line
traces an essentially immortal lineage. Genomic instability in somatic cells increases with …

It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic
alterations, and loss of proteostasis—exist that describe the cellular aging process. Adding …