Thymoquinone: A small molecule from nature with high therapeutic potential

S Malik, A Singh, P Negi, VK Kapoor - Drug discovery today, 2021 - Elsevier
Abstract Thymoquinone (TQ; 2-isopropyl-5-methylbenzo-1, 4-quinone), the main active
constituent of Nigella sativa, has been proven to have great therapeutic properties in …

Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2

A Hashemzadeh, F Amerizadeh, F Asgharzadeh… - Toxicology and Applied …, 2021 - Elsevier
Oxaliplatin is being used in different malignancies and several side effects are reported for
patients taking Oxaliplatin, including peripheral neuropathy, nausea and vomiting, diarrhea …

Thymoquinone protects against cardiac mitochondrial DNA loss, oxidative stress, inflammation and apoptosis in isoproterenol-induced myocardial infarction in rats

AA Khalifa, RM Rashad, WF El-Hadidy - Heliyon, 2021 - cell.com
Introduction Myocardial infarction (MI) is an ischemic life-threatening disease with
exaggerated oxidative stress state that vigorously damages the cardiomyocyte membrane …

Thymoquinone-PLGA-PVA nanoparticles ameliorate bleomycin-induced pulmonary fibrosis in rats via regulation of inflammatory cytokines and iNOS signaling

SAM Saghir, NA Al-Gabri, AF Khafaga, NH El-Shaer… - Animals, 2019 - mdpi.com
Simple Summary In this study, we evaluated the role of thymoquinone-PLGA-PVA
nanoparticles (TQ-PLGA-PVA-NPs) in the amelioration of lung fibrosis induced …

[HTML][HTML] Anxiolytic and anti-inflammatory role of thymoquinone in arsenic-induced hippocampal toxicity in Wistar rats

F Firdaus, MF Zafeer, M Ahmad, M Afzal - Heliyon, 2018 - cell.com
Arsenic (As) is a widely existing metalloid in the biosphere. Drinking water contamination by
arsenic is a major route of human exposure, either by natural means or through industrial …

Çörek otunun (Nigella sativa L.) aktif bileşeni timokinonun insan sağlığı üzerine olası etkileri

P GÜZELSOY, S AYDIN… - Journal of Literature …, 2018 - turkiyeklinikleri.com
Bitki antioksidanları, en az yan etkileri ve besin takviyesi olarak önemli rolleri nedeni ile son
zamanlarda popülarite kazanmıştır. Timokinon, Nigella sativa L.(çörek otu) tohumunun …

Thymoquinone alleviates liver fibrosis via mir‐30a‐mediated epithelial‐mesenchymal transition

W Geng, C Li, Y Zhan, R Zhang… - Journal of cellular …, 2021 - Wiley Online Library
Thymoquinone (TQ), the main active constituent of Nigella sativa seeds, has been shown to
play a role in antioxidation, anti‐inflammation, and antitumor. Recent studies have …

[HTML][HTML] Protective effects of hydro-alcoholic extract of Zataria multiflora on lipopolysaccharide-induced inflammation and oxidative stress in rat liver

Z Arab, H Salmani, N Marefati, F Beheshti… - Avicenna Journal of …, 2023 - ncbi.nlm.nih.gov
Objective: Liver is an important player in regulation of body homeostasis. Study investigated
the effects of hydro-alcohol extract of Zataria multiflora (ZM) on oxidative damage, level of IL …

[HTML][HTML] Sulfasalazine colon-specific drug delivery by selenium nanoparticle

A Hashemzadeh, F Asgharzadeh, A Yaghoubi… - Journal of Trace …, 2022 - Elsevier
Background The goal was to assess the specific colon delivery and investigation of
synergistic anti-inflammatory effects of the selenium nanoparticle (SeNPs) as a bioactive …

[PDF][PDF] Thymoquinone attenuates immune mediated liver injury induced by Concanavalin A in mice

HA Ahmad, SH Kathem - Iraqi Journal of Pharmaceutical Sciences (P-ISSN …, 2021 - iasj.net
Autoimmune hepatitis is an inflammatory disease and its incidence has been increasing.
The features of hepatitis are the release of inflammatory cytokines, the elevation of AST and …