Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading
cause of cognitive impairment, the mechanisms of which remain poorly understood. In the …

Hypertension is one of the most prevalent cardiovascular disorders worldwide, affecting 1.13
billion people, or 14% of the global population. Hypertension is the single biggest risk factor …

The N-terminal portion of the octapeptide angiotensin II (DRVYIHPF; AngII), a vasopressor
peptide that favorably binds to, and activates, AngII type 1 receptor (AT1R), has an important …

Objective We aimed to evaluate the prognostic performance of circulating Klotho in coronary
atherosclerotic disease (CAD), and to further explore the effect of Klotho on stress-mediated …

For salt-sensitive hypertension (SSH), salt restriction and angiotensin-converting enzyme
(ACE) inhibitors are essential treatments, but their effect on the function of resistance arteries …

Purpose Primary aldosteronism (PA) is the most frequent form of secondary hypertension.
Hypertension is a risk factor for cognitive decline and dementia. White matter lesions …

Many therapeutic strategies are developed for the major health problems and the key
enzyme inhibitory theory is one of the most applied approaches. One of the aspects of the …

脑血管功能异常是阿尔茨海默病(AD) 重要的病理特征之一, 而脑肾素-血管紧张素系统(BRAS)
病理改变则是AD 患者脑血管损伤的重要指标. BRAS 相对独立于外周肾素 …

Hypertension, a disease afflicting over one billion individuals worldwide, is a leading cause
of cognitive impairment, the mechanisms of which remain poorly understood. In a mouse …

The renin–angiotensin–aldosterone system (RAAS) plays a critical role in the regulation of
many physiological functions. Furthermore, dysregulation of the RAAS is known to promote …