Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …

Metabolic reprogramming is a hallmark of cancer. Oncogenic growth signaling regulates
glucose, glutamine and lipid metabolism to meet the bioenergetics and biosynthetic …

Background A reduction in the availability of cholesterol may limit the cellular proliferation
required for cancer growth and metastasis. We tested the hypothesis that statin use begun …

The importance of cancer metabolism has been appreciated for many years, but the
intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully …

Prostate cancer risk can be modified by environmental factors, however the molecular
mechanisms affecting susceptibility to this disease are not well understood. As a result of a …

Pontén F, Schwenk JM, Asplund A, Edqvist P‐HD (Uppsala University, Uppsala; and KTH–
Royal Institute of Technology, Stockholm; Sweden). The Human Protein Atlas as a proteomic …

The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence
suggests that cholesterol plays critical roles in the progression of cancers, including breast …

Phosphatidylinositol 3′-kinase (PI3K) and Akt are signaling kinases involved in cell
survival and proliferation. Recent evidence suggests that PI3K/Akt activates the sterol …

Importance Preclinical and epidemiological studies indicate a potential chemopreventive
role of statins in epithelial ovarian cancer risk. Objective To evaluate the association of …

Background Statin therapy reduces the risk of occlusive vascular events, but uncertainty
remains about potential effects on cancer. We sought to provide a detailed assessment of …