Research Progress on TRPA1 in Diseases

J Li, H Zhang, Q Du, J Gu, J Wu, Q Liu, Z Li… - The Journal of …, 2023 - Springer
For a long time, the physiological activity of TRP ion channels and the response to various
stimuli have been the focus of attention, and the physiological functions mediated by ion …

Drug delivery strategies for the treatment of pancreatic cancer

O Olajubutu, OD Ogundipe, A Adebayo, SK Adesina - Pharmaceutics, 2023 - mdpi.com
Pancreatic cancer is fast becoming a global menace and it is projected to be the second
leading cause of cancer-related death by 2030. Pancreatic adenocarcinomas, which …

STING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancer

Y Da, Y Liu, Y Hu, W Liu, J Ma, N Lu, C Zhang… - …, 2022 - Taylor & Francis
Activation of the stimulator of interferon gene (STING)-mediated innate immune response
has been suggested as a promising therapeutic strategy for cancers. However, the effects of …

Contrast-Enhanced Harmonic Endoscopic Ultrasound-Guided Puncture for the Patients with Pancreatic Masses

Y Otsuka, K Kamata, M Kudo - Diagnostics, 2023 - mdpi.com
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is useful for the diagnosis
of pancreatic masses. According to three meta-analyses, the sensitivity, specificity, and …

LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc

C Cheng, Z Liu, D Liu, H Chen, Y Wang… - Carcinogenesis, 2024 - academic.oup.com
Long noncoding RNAs (lncRNAs) play fundamental roles in cancer development; however,
the underlying mechanisms for a large proportion of lncRNAs in pancreatic ductal …

GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer

S Han, C Cao, R Liu, YF Yuan, L Pan, M Xu, C Hu… - Cellular Oncology, 2022 - Springer
Purpose GAS41 is a YEATS domain protein that binds to acetylated histone H3 to promote
the chromatin deposition of H2A. Z in non-small cell lung cancer. The role of GAS41 in …

Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: New sights to clinical decision-making

J Zhu, Y Shi, S Lan, J Wang, F Jiang, C Tang, Y Cai… - Apoptosis, 2023 - Springer
Recent studies have indicated that pyroptosis may participate in the regulation of
tumorigenesis and immune microenvironment. However, the role of pyroptosis-related …

Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review

CP Dash, D Sonowal, P Dhaka, R Yadav… - Frontiers in …, 2024 - frontiersin.org
Recent advancements in genetic engineering have made it possible to modify Natural Killer
(NK) cells to enhance their ability to fight against various cancers, including solid tumors …

Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing Notch1 degradation and downregulating key vasculogenic genes

J Qi, M Meng, J Liu, X Song, Y Chen, Y Liu, X Li… - Biochemical …, 2023 - Elsevier
Pancreatic cancer is highly metastatic and lethal with an increasing incidence globally and a
5-year survival rate of only 8%. One of the factors contributing to the high mortality is the lack …

A benzochalcone derivative synchronously induces apoptosis and ferroptosis in pancreatic cancer cells

X Guan, B Zhao, X Guan, J Dong, J Ying - PeerJ, 2023 - peerj.com
Background Pancreatic cancer is a highly aggressive and lethal disease with limited
treatment options. In this study, we investigated the potential therapeutic effects of …