Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

Objective: To carry out a systematic review of the risk factors for, and incidence of, major
depressive episode (MDE) related to antiviral therapy for chronic hepatitis C. Data Sources …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, being characterized by the progressive loss of dopaminergic neurons in the …

Administration of the cytokines interferon-α and interleukin-2 is used for the treatment of
various disorders, such as hepatitis C and various forms of cancer. The most serious side …

When I was about fifteen, my Biological Seiences teacher, Prof. N. Benacchio, lent me a
book by Paul de Kruif" The Microbe Hunters" and I remained fascinated by infectious …

Hepatitis C viral infection is a global health problem that affects approximately 4 million
people in the United States. Combination treatment with pegylated interferon (IFN)-α plus …

Stress has been shown to suppress immune function and increase susceptibility to
inflammatory disease and psychiatric disease. CD4+ CD25+ regulatory T (Treg) cells are …

The objective of the present study was to investigate the relation between adipose tissue
polyunsaturated fatty acids, an index of long-term or habitual fatty acid dietary intake, and …

BACKGROUND: Major depressive disorder (MDD) occurs in a subset of patients receiving
interferon-alpha treatment, although many are resilient to this side effect. Genetic differences …

OBJECTIVE: Interferon-α2 (IFN-α) injections may be capable of triggering depression in
some individuals. The first objective was to further characterize this depression and …