Lipoprotein (a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment

S Lampsas, M Xenou, E Oikonomou, P Pantelidis… - Molecules, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) is a low-density lipoprotein (LDL) cholesterol-like particle bound to
apolipoprotein (a). Increased Lp (a) levels are an independent, heritable causal risk factor …

[HTML][HTML] Daring to dream: Targeting lipoprotein (a) as a causal and risk-enhancing factor

ML Koschinsky, ESG Stroes, F Kronenberg - Pharmacological Research, 2023 - Elsevier
Abstract Lipoprotein (a)[Lp (a)], a distinct lipoprotein class, has become a major focus for
cardiovascular research. This review is written in light of the recent guideline and consensus …

Lipoprotein (a) in youth and prediction of major cardiovascular outcomes in adulthood

O Raitakari, N Kartiosuo, K Pahkala, N Hutri-Kähönen… - Circulation, 2023 - Am Heart Assoc
Background: Elevated lipoprotein (a)[Lp (a)] is a common risk factor for cardiovascular
disease outcomes with unknown mechanisms. We examined its potential role in identifying …

Lipoprotein (a) and cardiovascular disease in Chinese population: a Beijing heart society expert scientific statement

JJ Li, CS Ma, D Zhao, XW Yan - JACC: Asia, 2022 - jacc.org
Elevated concentration of lipoprotein (a)[Lp (a)] is an independent risk factor for
atherosclerotic cardiovascular disease, including coronary artery disease, stroke, peripheral …

The role of high-density lipoprotein cholesterol in 2022

CR Sirtori, A Corsini, M Ruscica - Current atherosclerosis reports, 2022 - Springer
Abstract Purpose of the Review High-density lipoproteins (HDL) are responsible for the
transport in plasma of a large fraction of circulating lipids, in part from tissue mobilization …

Omega-3 and cardiovascular prevention–Is this still a choice?

M Ruscica, CR Sirtori, S Carugo, PC Calder… - Pharmacological …, 2022 - Elsevier
There is currently growing attention being paid to the role of elevated triglycerides (TGs) as
important mediators of residual atherosclerotic cardiovascular disease (ASCVD) risk. This …

[PDF][PDF] Low lipoprotein (a) levels predict hepatic fibrosis in patients with nonalcoholic fatty liver disease

M Meroni, M Longo, R Lombardi… - Hepatology …, 2022 - Wiley Online Library
Dyslipidemia and cardiovascular complications are comorbidities of nonalcoholic fatty liver
disease (NAFLD), which ranges from simple steatosis to nonalcoholic steatohepatitis …

RNA-based therapy in the management of lipid disorders: a review

DJ Blom, AD Marais, R Moodley… - Lipids in Health and …, 2022 - Springer
This review focuses on antisense oligonucleotides and small interfering ribonucleic acid
therapies approved or under development for the management of lipid disorders. Recent …

Updates in small interfering RNA for the treatment of dyslipidemias

S Carugo, CR Sirtori, G Gelpi, A Corsini… - Current Atherosclerosis …, 2023 - Springer
Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the
leading cause of death worldwide. Despite excellent pharmacological approaches, clinical …

Low-density lipoprotein cholesterol-lowering drugs: a narrative review

N Ferri, M Ruscica, S Fazio, A Corsini - Journal of Clinical Medicine, 2024 - mdpi.com
The modern history of cholesterol-lowering drugs started in 1972 when Dr. Akira Endo
identified an active compound (compactin) that inhibited cholesterol biosynthesis from the …