Drug delivery challenges and current progress in nanocarrier-based ocular therapeutic system

MH Akhter, I Ahmad, MY Alshahrani, AI Al-Harbi… - Gels, 2022 - mdpi.com
Drug instillation via a topical route is preferred since it is desirable and convenient due to the
noninvasive and easy drug access to different segments of the eye for the treatment of …

Impact of protein corona on the biological identity of nanomedicine: understanding the fate of nanomaterials in the biological milieu

MH Akhter, H Khalilullah, M Gupta, MA Alfaleh… - Biomedicines, 2021 - mdpi.com
Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a
number of protein molecules resulting in the formation of an NP–protein complex called …

Design-of-experiment-assisted fabrication of biodegradable polymeric nanoparticles: in vitro characterization, biological activity, and in vivo assessment

MA Mir, MH Akhter, O Afzal, SO Rab, ASA Altamimi… - ACS …, 2023 - ACS Publications
Berberine (BER) is an alkaloid obtained from berberis plant having broad biological
activities including anticancer. BER-encapsulated alginate (ALG)/chitosan (CHS) …

A β–Sitosterol encapsulated biocompatible alginate/chitosan polymer nanocomposite for the treatment of breast Cancer

O Afzal, MH Akhter, I Ahmad, K Muzammil, A Dawria… - Pharmaceutics, 2022 - mdpi.com
β–sitosterol is the most abundant type of phytosterol or plant sterol and can be found in
various plant dietary sources including natural oils, soy products, and nuts. Numerous …

Phytosterol-loaded surface-tailored bioactive-polymer nanoparticles for cancer treatment: Optimization, in vitro cell Viability, antioxidant activity, and stability studies

S Karim, MH Akhter, AS Burzangi, H Alkreathy… - Gels, 2022 - mdpi.com
This study aimsto optimize, characterize, and assess the phytosterol-loaded surface-tailored
bioactive Alginate/Chitosan NPs for antitumor efficacy against breast cancer. β-Sitosterol …

Surface-modified biobased polymeric nanoparticles for dual delivery of doxorubicin and gefitinib in glioma cell lines

M Farheen, MH Akhter, H Chitme, M Suliman… - ACS …, 2023 - ACS Publications
Glioma is a malignant form of brain cancer that is challenging to treat due to the progressive
growth of glial cells. To target overexpressed folate receptors in glioma brain tumors, we …

Harnessing folate-functionalized nasal delivery of dox–erlo-loaded biopolymeric nanoparticles in cancer treatment: development, optimization, characterization, and …

M Farheen, MH Akhter, H Chitme, MS Akhter… - Pharmaceuticals, 2023 - mdpi.com
The aim of the present study is to develop Doxorubicin–Erlotinib nanoparticles (Dox–Erlo
NPs) and folate-armored Dox–Erlo-NP conjugates for targeting glioma cancer. Glioma is …

Development, characterization, and evaluation of α-Mangostin-loaded polymeric nanoparticle gel for topical therapy in skin Cancer

S Md, NA Alhakamy, T Neamatallah, S Alshehri… - Gels, 2021 - mdpi.com
The aim of this study was to prepare and evaluate α-mangostin-loaded polymeric
nanoparticle gel (α-MNG-PLGA) formulation to enhance α-mangostin delivery in an …

Nanotechnology-enabled therapies improve blood-brain barrier challenges in brain tumor

Y Wenqi, W Lingxi, A Mehmood… - International Journal of …, 2023 - Taylor & Francis
The treatment of brain tumors has been predominantly hindered by the limited ability of
drugs to penetrate the blood-brain barrier. However, recent advancements in …

Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer

S Ren, L Song, Y Tian, L Zhu, K Guo… - International Journal …, 2021 - Taylor & Francis
Background Pancreatic cancer (PC) remains a difficult tumor to diagnose and treat. It is often
diagnosed as advanced by reason of the anatomical structure of the deep retroperitoneal …