Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …

Cancer-associated fibroblasts (CAFs) are the most abundant cells in the tumor
microenvironment. Crosstalk between tumor cells and CAFs contributes to tumor survival in …

Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …

The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

Simple Summary The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR)
system represents an emerging therapeutic target in breast cancer. Here, we discussed …

Simple Summary Anti-angiogenic therapies targeting the vascular endothelial growth factor
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …

Background: Hormone receptor-positive and HER2-negative breast cancer (HR+ BC) is the
most prevalent breast cancer. Endocrine therapy is the mainstay of treatment, however, due …