1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Background Smoking is one of the leading causes of millions of deaths worldwide. During
cigarette smoking, most affected and highly exposed cells are the alveolar epithelium and …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β 2-agonists
is highly effective, safe and relatively inexpensive, but for many patients, their disease …

Effective treatment of severe asthma is a major unmet need because patients' symptoms are
not controlled on maximum treatment with inhaled therapy. Asthma symptoms can be poorly …

Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …

Essential fatty acids (EFA) play a critical role in the brain and regulate many of the processes
altered in Alzheimer's disease (AD). Technical advances are allowing for the dissection of …

BACKGROUND: There is evidence that inflammation, oxidative and nitrosative stress
(IO&NS) play a role in the pathophysiology of depression. There are also data indicating …

Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …